📄 Category

developmental biology

216 papers

Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.

At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.

Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.

📄 developmental biology

From Variability to Synchrony: Non-linear Development of Auditory Neural Responses During the First Year of Life

This longitudinal high-density EEG study of 69 infants reveals that auditory neural maturation during the first year of life follows a non-linear trajectory characterized by increasing response strength and reduced variability, alongside a dynamic shift in phase synchronization that initially improves temporal alignment before decreasing to facilitate more differentiated brain activity.

Reisenberger, E., Schabus, M., Florea, C., Angerer, M., Reimann-Ayiköz, M., Preiss, J., Roehm, D., Heib, D. P. J., Faze (…)2026-03-04
📄 developmental biology

Exploration of the screening and regulatory mechanisms of biomarkers related to ac4C modification in laryngeal squamous cell carcinoma patients based on single-cell analysis and machine learning

This study integrates single-cell analysis and machine learning to identify seven ac4C-related prognostic genes in laryngeal squamous cell carcinoma that modulate the tumor immune microenvironment and serve as potential therapeutic targets.

Wang, L., Gong, X., Chen, D., Chen, X., Zhou, H., Lan, J., Ye, R., Luo, Z., Shi, Y.2026-03-03
📄 developmental biology

ZNHIT1-dependent H2A.Z deposition at meiotic prophase I underlies pachytene gene expression and meiotic progression during male meiosis

This study identifies ZNHIT1 as a critical chromatin remodeler that ensures successful male meiosis by facilitating H2A.Z deposition, which cooperates with the transcription factor A-MYB to regulate pachytene gene expression and enable proper homologous recombination.

Sun, S., Jiang, Y., Jiang, N., Zhang, Q., Pan, H., Huang, F., Zhang, X., Guo, Y., You, X., Gong, K., Wei, W., Liu, H., S (…)2026-03-02
📄 developmental biology

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development.

This paper introduces FuChi, a novel transgenic chicken line equipped with an optimized multicistronic Fucci biosensor that enables precise, real-time tracking of all cell cycle phases in live embryos, thereby revealing critical proliferation dynamics during avian development and establishing a superior in vivo model for studying cell-cycle kinetics.

Sudderick, Z. R., Briggs, T., Mubarak, S., Van Kerckvoorde, M., Hernandez Rodriguez, A. R., Panda, S. K., Riddell, J., B (…)2026-03-02
📄 developmental biology

A Single-Cell Transcriptomic Atlas of Symmetry Breaking Across Eutherian Mammals

This study presents a cross-species single-cell transcriptomic atlas of sheep and other eutherian mammals that reveals conserved signaling pathways and species-specific variations in symmetry breaking, establishing sheep as a vital model for understanding human peri-implantation development.

Gonzalez-Brusi, L., Martinez de los Reyes, N., Marigorta, P., Simpson, L., Toledano-Diaz, A., Santiago-Moreno, J., Alber (…)2026-03-02
📄 developmental biology

Cone photoreceptor ablation in microglia-deficient larval zebrafish retina elicits a regenerative response alongside a compensatory immune cell response

This study demonstrates that while cone photoreceptor ablation in microglia-deficient larval zebrafish triggers a compensatory immune response and only modestly affects Müller glia proliferation and cone regeneration, the presence of these alternative immune cells limits definitive conclusions about microglia's specific role in retinal regeneration.

Rumford, J. E., Farre, A. A., Mai, J., Weimar, H. V., Shelton, C. D., Morales, M., Mitchell, D. M.2026-03-01
📄 developmental biology

Genome wide transcriptional changes underlie gradual and recurrent adaptation to protein malnutrition in zebrafish

This study demonstrates that zebrafish can gradually overcome a heritable defect in intestinal protein absorption through recurrent, genome-wide transcriptional changes that hyperactivate endocytic components in specialized enterocytes while simultaneously recalibrating immune responses to ensure survival despite protein malnutrition.

Wang, S., Childers, L., Martinez, F., Bagnat, M., Park, J.2026-03-01
📄 developmental biology

Tissue composition shapes differential skeletal integration strategies during axolotl limb regeneration

This study reveals that the tissue composition at the axolotl amputation plane dictates distinct skeletal integration strategies by triggering osteoclast-mediated resorption specifically in calcified regions through the upregulation of RANKL and Ccl24-like, thereby ensuring seamless regeneration regardless of the injury site.

Aires, R., Keeley, S. D., Brandt, K., Carreira, M., Günes, D. B., Savci, Y., Friedrich, U. A., Dahl, A., Aztekin, C., S (…)2026-02-27